Glutathione and Immunocal Clinical Trials

 

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Scientific Research & Clinical Trials Documentation

In the last twenty years the volume of research into GSH has grown immensely. A huge variety of theoretical papers, bench-top laboratory experiments, epidemiological studies and—most importantly—clinical trials on humans, has linked glutathione to an extraordinary variety of illnesses. The list is long and would be hard to believe were it not for the strength and credibility of the research.


Hundreds of articles have described how elevated glutathione levels help combat the infirmities of aging, such as Parkinson’s disease, Alzheimer’s disease, cataract formation, macular degeneration, and cancers of aging (e.g. prostate cancer). Glutathione depletion is linked with the major causes of morbidity and mortality in North America, including heart disease, stroke, diabetes and infectious disease. Many different medical specialists are paying special attention to natural glutathione modulation, as more traditional means have proven less than efficient.

 

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Competition for glutathione

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The use of a whey protein concentrate in the treatment of patients with metastaticcarcinoma:  a phase I-II clinical study

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Whey proteins as a food supplement in HIV-seropositive individuals

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The biological activity of undenatured dietary whey proteins: role of glutathione

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Whey proteins in cancer prevention

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Dietary milk proteins inhibit the development of Dimethylhydrazine-induced malignancy

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The influence of dietary whey protein on tissue: glutathione and the disease of aging

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Immunoenhancing property of dietary whey protein in mice: role of glutathione

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The immunoenhancing property of dietary whey protein concentrate

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Dietary whey protein inhibits the development of dimethylhydrazine inducedmalignancy

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Mechanism of altered B-cell response induced by changes in dietary protein type in mice

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Differential effect of dietary protein type on the B-cell and T-cell immune response in mice

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Influence of dietary protein type on the immune system of mice

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Changes in biliary secretory immunoglobulins A in mice fed whey protein

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Place for an antioxidant therapy in human immunodeficiency virus (HIV) infection

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Influence of dietary lactalbumin hydrolysate on the immune system of mice andresistance to salmonellosis

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Effect of supplementation with a cysteine donor on muscular performance

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Treatment of obstructive airway disease with a cysteine donor protein supplement

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Treatment of chronic hepatitis using whey protein (non-heated)

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Whey protein concentrate (WPC) and glutathione modulation in cancer treatment

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Enhancing effect of patented whey protein isolate (Immunocal) on cytotoxicity of an anticancer drug

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Nutriceutical modulation of Glutathione with a humanized native milk serum protein isolate, Immunocal"!: application in AIDS and cancer

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The antioxidant system

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Milk whey protein decreases oxygen free radical production in a murine model ofchronic iron-overload cardiomyopathy

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Molecular pathogenesis and prevention of prostate cancer

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Improved glutathione status in young adult patients with cystic fibrosis supplemented with whey protein

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Research GlutaHealth Liver Dieseas, Pulmonary Illnesses, Neurological Disorders, Aging.

 

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Scientific Research Grouped by Illnesses

 

 

Respiratory & Lung Disorders

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Oxidative stress and regulation of glutathione in lung inflammation.

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Regulation of glutathione in inflammation and chronic lung diseases.

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Environmental toxicity, redox signaling and lung inflammation: the role of glutathione.

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Significance of glutathione in lung disease and implications for therapy.

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Effects of cysteine donor supplementation on exercise induced Bronchoconstriction

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Treatment of Obstructive Airway disease with a cysteine donor protein supplement a case report

 

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Aids & Cancer

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Common Antioxidant May Decrease Risk of Breast Cancer

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Molecular pathogenesis and prevention of prostate cancer.

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Low colonic glutathione detoxification capacity in patients at risk for colon cancer

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The glutathione biotransformation system and colorectal cancer risk in humans

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Antioxidants and Cancer Prevention fact sheet national cancer institute

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Dietary milk proteins inhibit the development of dimethylhydrazine-induced malignancy (Tumor Growth)

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Dietary whey protein inhibits the development of dimethylhydrazine induced malignancy (Tumor Growth)

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Enhancing effect of patented whey protein isolate immunocal on cytotoxicity of an Anticancer drug

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Nutriceutical modulation of glutathione with a humanized native milk serum protein isolate AIDs and Cancer

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The antioxidant system

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The use of a whey protein concentrate in the treatment of patients with Metastatic Carcinoma

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Whey protein concentrate and glutathione modulation in cancer treatment

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Whey proteins in cancer prevention

 

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Cystic Fibrosis

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Improved glutathione status in young adult patients with cystic fibrosis supplemented with whey protein.

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Systemic deficiency of glutathione in cystic fibrosis.

 

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Depression & Bipolar

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N-acetyl cysteine for depressive symptoms in bipolar disorder--a double-blind randomized placebo-controlled trial.

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Antioxidant enzyme activities and oxidative stress in affective disorders.

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Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments.

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Antioxidative enzymes and increased oxidative stress in depressive women.

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Antioxidant enzyme and malondialdehyde levels in patients with panic disorder.

 

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Diabetes

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Negative association between erythrocyte reduced glutathione concentration and diabetic complications.

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 Pro-, antioxidant and filtration changes in the blood of type 1 diabetic patients.

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Diabetes and Glutathione Status

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Diabetes Oxidative Stress and Antioxidants A Review

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Effect of inhibition of glutathione synthesis on insulin action in vivo and in vitro studies using buthionine sulfoximine

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Effect of whey on blood glucose and insulin responses to composite breakfast and lunch meals in Type 2 Diabetic subjects

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Evidence for Accelerated Rates of Glutathione Utilization and Glutathione Depletion in Adolescents With Poorly Controlled Type 1 Diabetes

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Up-regulation of K channels in diabetic rat ventricular myocytes by insulin and glutathione

 

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Fatigue

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Competition for glutathione precursors between the immune systemand the skeletal muscle pathogenesis of chronic fatigue syndrome

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Effect of supplementation with a cysteine donor on muscular performance

 

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High Blood Pressure

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Link found between excess free radicals high blood pressure

 

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HIV/Aids

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Effects of long-term supplementation with whey proteins on plasma glutathione levels of HIV-infected patients.

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Products to safely increase lean muscle mass.

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Antioxidant therapy for AIDS

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Bioactive Cysteine Rich Dietary Supplement Alleviates Gastrointestinal Side Effects with Associated Weight Gain and Marked Improvement in HAART Adherence in AIDS Patients

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Canadian AIDS Treatment Information Exchange Fact Sheet Whey Protein

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Glutathione as it relates to hiv aids

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Nutriceutical modulation of glutathione with a humanized native milk serum protein isolate AIDs and Cancer

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Place for an antioxidant therapy in human immunodeficiency virus

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Whey proteins as a food supplement in hiv-seropositive individuals

 

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Kidney Disease

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Oxidative stress and damage induced by abnormal free radical reactions and IgA nephropathy.

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Distribution of glutathione peroxidase in the glomeruli of IgA nephropathy

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Advanced oxidation protein products accelerate renal fibrosis in a remnant kidney model.

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Glutathione antioxidant system as a marker of oxidative stress in chronic renal failure.

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Oxidative stress in chronic renal failure.

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Glutathione peroxidase activity and reduced glutathione content in erythrocytes of patients with chronic renal failure.

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Systemic human diseases as oxidative risk factors in cataractogenesis. II. Chronic renal failure.

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Oxidant mechanisms in toxic acute renal failure.

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Red blood cell and plasma glutathione peroxidase activities and selenium concentration in patients with chronic kidney disease: a review.

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Simultaneous inhibition of renal phospholipase A(2) and glutathione synthesis by manoalide and DL-buthionine sulfoximine induces acute tubular dysfunction in rats.

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Role of glutathione in an animal model of myoglobinuric acute renal failure.

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Expression of glomerular antioxidant enzymes in human glomerulonephritis.

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Antioxidative treatment retards progression of idiopathic membranous nephropathy

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Antioxidant therapy in glomerular disease

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Low whole blood and erythrocyte levels of glutathione in hemodialysis and peritoneal dialysis patients.

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Haemolysis in haemodialysis patients: evidence for impaired defence mechanisms against oxidative stress.

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Lupus

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Oxidative protein damage and antioxidant status in systemic lupus erythematosus.

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Correlation of lipid peroxidation and glutathione levels with severity of systemic lupus erythematosus: a pilot study from single center.

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Mitochondrial dysfunction in T cells of patients with systemic lupus erythematosus.

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Lipid peroxidation in systemic lupus erythematosus.

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Oxidant stress, anti-oxidants and essential fatty acids in systemic lupus erythematosus.

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Serum oxidant/antioxidant status of patients with systemic lupus erythematosus.

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Oxidative stress: the paradox of aerobic life.

 

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Neurological Disorders

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Oxidative stress in Parkinson's disease and other neurodegenerative disorders.

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Molecular bases of the treatment of Alzheimer's disease with antioxidants: prevention of oxidative stress.

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Characterization of intracellular elevation of glutathione (GSH) with glutathione monoethyl ester and GSH in brain and neuronal cultures: relevance to Parkinson's disease.

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The effects of stress and aging on glutathione metabolism

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Glutathione in Parkinson's disease: a link between oxidative stress and mitochondrial damage?

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Parkinson's disease: a disorder due to nigral glutathione deficiency?

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Dopamine turnover and glutathione oxidation: implications for Parkinson disease.

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Alterations in glutathione levels in Parkinson's disease and other neurodegenerative disorders affecting basal ganglia.

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Glutathione peroxidase in early and advanced Parkinson's disease.

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Reduced intravenous glutathione in the treatment of early Parkinson's disease.

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Mitochondrial impairment as an early event in the process of apoptosis induced by glutathione depletion in neuronal cells: relevance to Parkinson's disease.

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Glutathione--a review on its role and significance in Parkinson's disease.

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Glutathione and Parkinson's disease: is this the elephant in the room?

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Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients.

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Idiopathic Parkinson's disease, progressive supranuclear palsy and glutathione metabolism in the substantia nigra of patients.

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Glutathione oxidative stress and neurodegeneration
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GSH dopamine and glutamate roles in parkinsons disease
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Metabolism and functions of glutathione in brain
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Neurodegenerative diseases alzheimer and parkinson
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Neurodegenerative disorders gsh prevention of neuronal death

 

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Prostate

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GSTA1 expression in normal, preneoplastic, and neoplastic human prostate tissue

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Preneoplastic prostate lesions: an opportunity for prostate cancer prevention

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ATAAA repeat upstream of glutathione S-transferase P1 and prostate cancer risk

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A possible regulatory role of glyoxalase I in cell viability of human prostate cancer.

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Glutathione System in Defense of Prostate Problems

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Identification of potential prostate cancer preventive agents through induction of quinone reductase in vitroPotent induction of phase 2 enzymes in human prostate cells by sulforaphane

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Potent induction of phase 2 enzymes in human prostate cells by sulforaphane

 

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